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Association between tobacco use and recurrent aphthous stomatitis: a systematic review protocol
Venkitachalam Ramanarayanan1,2, Parvathy Balachandran1, Kalyani Biju1
1Department of Public Health Dentistry, Amrita School of Dentistry, Kochi, Kerala, India.
JBI Evidence Synthesis
|May 20, 2025
Summary
This review examines if tobacco use increases the risk of recurrent aphthous stomatitis (RAS), commonly known as mouth ulcers. Findings will clarify the link between smoking and this oral condition.
Area of Science:
- Oral Medicine
- Public Health
- Epidemiology
Background:
- Recurrent aphthous stomatitis (RAS) is a prevalent oral condition characterized by recurring mouth ulcers.
- Tobacco use is a known risk factor for various oral lesions, but its specific association with RAS remains debated in scientific literature.
Purpose of the Study:
- To systematically evaluate the existing evidence on whether tobacco use acts as a risk factor for developing recurrent aphthous stomatitis (RAS).
Main Methods:
- A systematic review methodology will be employed, adhering to JBI guidelines for risk factor reviews.
- Inclusion of primary studies (cross-sectional, case control, cohort, experimental) with clinically diagnosed RAS, regardless of age, tobacco type, publication year, or location.
- Comprehensive literature search across major databases (MEDLINE, CINAHL, PsycINFO, Scopus, etc.), followed by rigorous study selection, quality appraisal (JBI risk of bias tools), and data extraction.
- Quantitative synthesis using measures such as odds ratio and relative risk to assess the association between tobacco use and RAS.
Main Results:
- This section is to be populated upon completion of the review.
Conclusions:
- This section is to be populated upon completion of the review.
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