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Clinical Outcomes and Quality of Life in Children with Central Precocious Puberty: A Pragmatic Analysis

Parikshit Sen1, Aashima Dabas1, Ravindra Kumar2

  • 1Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.

Journal of Obstetrics and Gynaecology of India
|May 20, 2025
PubMed

Insights

Central precocious puberty (CPP) treatment with gonadotropin releasing hormone analog (GnRHa) leads to favorable growth and normal puberty resumption. Early GnRHa therapy is linked to better quality of life outcomes in children with CPP.

Area of Science:

  • Pediatric Endocrinology
  • Reproductive Medicine
  • Child Growth and Development

Background:

  • Central precocious puberty (CPP) presents variable growth and pubertal outcomes influenced by treatment. Understanding these outcomes is crucial for optimizing therapeutic strategies.
  • Assessing the impact of gonadotropin releasing hormone analog (GnRHa) therapy on anthropometric measures and pubertal progression in children with CPP is essential.

Purpose of the Study:

  • To evaluate growth and pubertal progression in children with CPP undergoing GnRHa therapy.
  • To correlate treatment outcomes with the quality of life in children with CPP.

Main Methods:

  • An observational study involving children with CPP treated with GnRHa.
  • Collection of baseline and follow-up clinical data, including anthropometric measurements and pubertal status.
  • Quality of life assessment using the PedsQL 4.0 questionnaire at the final follow-up visit.

Main Results:

  • A cohort of 23 children (21 girls, 2 boys) with CPP was studied, with a median follow-up of 4.4 years.
  • Treatment completion resulted in normal pubertal progression for 12 children. The bone age to chronological age ratio significantly decreased (p < 0.001).
  • Earlier GnRHa therapy initiation correlated with improved growth velocity (r = -0.598; p = 0.003). Quality of life scores were generally favorable but lower in shorter, older, or post-menarcheal girls.

Conclusions:

  • GnRHa therapy leads to favorable anthropometric outcomes and normal puberty resumption in children with CPP.
  • Early and adequate GnRHa treatment is associated with positive quality of life outcomes in this pediatric population.
Abstract

Keywords:
Height velocityLeuprorelinMenarchePedsQLPsychosocial

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