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[Plasma exchange therapy in hematology].

P Höcker, E Pittermann

    Wiener Klinische Wochenschrift
    |February 1, 1985
    PubMed
    Summary

    Plasma exchange (PE) is a vital emergency treatment for hyperviscosity syndrome and certain autoimmune blood disorders. Its effectiveness in other hematological conditions is less defined but can be used when standard treatments fail.

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    Area of Science:

    • Hematology
    • Immunology
    • Plasma Therapy

    Context:

    • Plasma exchange (PE) is a critical intervention for specific hematological emergencies.
    • Established indications include hyperviscosity syndrome, factor VIII antibody hemophilia, autoimmune hemolytic anemia, and post-transfusion purpura.

    Purpose:

    • To review the established and potential applications of plasma exchange in hematological disorders.
    • To delineate the role of PE in both clear-cut emergencies and less defined conditions.

    Summary:

    • PE is the primary treatment for acute hyperviscosity syndrome, factor VIII antibody hemophilia, autoimmune hemolytic anemia, and post-transfusion purpura.
    • The efficacy of PE in thrombotic thrombocytopenic purpura, immune thrombocytopenia, cryoglobulinemia, Rh incompatibility, autoimmune cytopenia, and AB0 incompatibility with bone marrow transplantation requires further definition.
    • PE serves as a therapeutic option in these less defined hematological disorders when conventional therapies are ineffective.

    Impact:

    • Provides clarity on the established role of PE in critical hematological conditions.
    • Highlights areas where PE's utility is less defined, guiding future research and clinical practice.
    • Emphasizes PE as a salvage therapy for refractory hematological disorders.

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