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Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
Published on: October 13, 2023
The Role of Adalimumab in Recurrent Pregnancy Loss Due Immune Dysregulation: A Case Series Report
Aruna Rajan1, S Ramakrishnan2, Madhumitha1
1A4 Fertility Centre, No 87 Arcot Road, AVM Avenue, VirugambakkamVadapalani, Chennai, 600092 India.
Abstract:
Tumor necrosis factor-alpha, a multifunctional T-helper 1 (Th1) cytokine, plays a significant role in placentation and embryonic development. Altered expression of TNF-α has been implicated in adverse pregnancy outcomes such as recurrent pregnancy loss (RPL) and pre-eclampsia (PE). The use of TNF-α inhibitors (TNFi) like Adalimumab (AD) has garnered attention for its ability to traverse the placental barrier, and modulating maternal immune responses during pregnancy. In this article, we have discussed two patients in whom the immunological factors have been identified in otherwise unexplained RPL and how the use of TNFi could be of help to achieve a viable pregnancy.
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