Related Experiment Video
Updated: May 22, 2025
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
Quantitative assessment of bladder tissue properties using magnetic resonance fingerprinting: a pilot feasibility
Eduardo Thadeu de Oliveira Correia1, Jad Badreddine1, Rasim Boyacioglu2
1University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Objective:
To investigate the feasibility of performing magnetic resonance fingerprinting (MRF) of the bladder and quantify the T1 and T2 relaxation times of the bladder wall in healthy female volunteers, before and after voiding.
Materials And Methods:
Volunteers without lower urinary tract symptoms underwent pelvic MRF. Five axial MRF slices of the bladder were obtained before and after voiding. Regions of interest were annotated on MRF T1 maps: one on the anterior bladder wall, and one on a lateral wall. Annotations made on T1 maps were subsequently copied to coregistered T2 maps. Student's t-tests for paired samples were employed to compare the T1 and T2 values obtained before voiding with those obtained after voiding.
Results:
Eight volunteers were included. The mean preand post-void T1 relaxation times were 1,575 ± 93 ms and 1,476 ± 138 ms, respectively. The mean preand post-void T2 relaxation times were 55 ± 21 ms and 53 ± 8 ms, respectively. The mean T1 relaxation times were 6% lower after voiding than before (p = 0.035).
Conclusion:
The use of MRF to quantify T1 and T2 relaxation times in the bladder appears to be feasible. Our results can serve as a reference for studies investigating T1 and T2 relaxation times in patients with malignant or nonmalignant bladder disorders.
