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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

620
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Updated: May 22, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Circulating CD8 T cells from patients with mild-to-moderate psoriasis are functionally impaired.

Yiqiao Chen1, Chiara Tontini1, Isabella Tosi2

  • 1Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Frontiers in Immunology
|May 20, 2025
PubMed
Summary

Psoriasis patients have fewer CD8 memory T cells and reduced cytotoxic mediator release. This indicates that psoriasis impairs the function of circulating CD8 T cells, impacting immune responses.

Keywords:
CD8 T cellsPASIflow cytometryimmunophenotypingmultiparametric analysisperipheral blood mononuclear cellspsoriasisunsupervised clustering

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Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Psoriasis is a systemic inflammatory skin disease driven by immune responses.
  • T cells, particularly CD8 T cells, are implicated in psoriasis pathogenesis.
  • The precise role and characteristics of circulating CD8 T cells in psoriasis remain unclear.

Purpose of the Study:

  • To investigate alterations in the phenotype, activation, and mediator release of CD8 T cells in the peripheral blood of individuals with mild-to-moderate psoriasis.
  • To compare CD8 T cell profiles between psoriasis patients and healthy controls.

Main Methods:

  • Peripheral blood mononuclear cells from psoriasis patients and healthy controls were analyzed using flow cytometry.
  • CD8 T cell phenotype and mediator release were assessed following in vitro TCR-dependent (anti-CD3/CD28) and TCR-independent (PMA/ION) activation.

Main Results:

  • Psoriasis patients exhibited a reduced frequency of circulating CD8 memory T cells.
  • Upregulation of B- and T-lymphocyte attenuator (BTLA) was observed on CD8 T cells in psoriasis patients.
  • Activated CD8 T cells from psoriasis patients showed decreased expression of CD69, IFNγ, and Granzyme B, along with a positive correlation between PASI scores and IFNγ-producing cells.

Conclusions:

  • Mild-to-moderate psoriasis is associated with a decrease in CD8 T memory cells and impaired cytotoxic mediator production.
  • These findings suggest that psoriasis significantly affects the functionality of circulating CD8 T cells.