Related Experiment Video

Updated: May 22, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.0K

Association between COVID-19 Mortality and Underlying Disease; Tehran, Iran

Alireza Atarodi1, Laleh R Kalankesh2, Leila Ghaderi Nansa3

  • 1Department of Knowledge and Information Science, Paramedical College and Social Development & Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.

Journal of Caring Sciences
|May 20, 2025
PubMed

Insights

This study found that underlying conditions like cancer and respiratory issues significantly increase COVID-19 mortality risk. Patients with cancer faced 4.72 times higher mortality, highlighting the impact of comorbidities on coronavirus outcomes.

Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Diseases

Background:

  • Coronavirus disease (COVID-19) presents a significant global health challenge.
  • Understanding the impact of pre-existing conditions on COVID-19 outcomes is crucial for patient management and public health strategies.

Purpose of the Study:

  • To investigate the association between COVID-19 mortality and various underlying diseases in Tehran.
  • To identify specific comorbidities that increase the risk of severe COVID-19 outcomes.

Main Methods:

  • A retrospective epidemiological study was conducted in Tehran, Iran, from January 2019 to May 2021.
  • Data from hospitals included International Classification of Diseases (ICD-11) codes for underlying conditions and patient demographics.
  • Logistic regression analysis was used to determine the association between COVID-19 mortality and underlying diseases.

Main Results:

  • Cancer and incurable diseases showed the lowest recovery rates, while pulmonary disease had the longest recovery time.
  • Cancer and pulmonary disease were associated with 10.41 and 7.3 hospitalization days, respectively.
  • Mortality risk was significantly higher for patients with cancer (4.72 times), respiratory issues (2.75 times), cardiovascular problems (4.081 times), and diabetes (3.162 times) as underlying conditions.

Conclusions:

  • Specific underlying health conditions substantially increase the risk of COVID-19 mortality.
  • Comorbidities like cancer, cardiovascular disease, respiratory illness, and diabetes are critical factors influencing COVID-19 severity and outcomes.
  • These findings underscore the importance of managing pre-existing conditions to mitigate COVID-19 mortality.
Abstract

Keywords:
COVID-19EpidemicsHospitalizationMortalityUnderlying

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.1K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.3K

Related Concept Videos

Causality in Epidemiology01:21

Causality in Epidemiology

Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
220
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.1K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
315
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
223
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
61
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
214