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Paternal Cardiometabolic Conditions and Perinatal Mortality
Shwe Sin Win1, Gerhard Sulo1, Anders Engeland1,2
1Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Paediatric and Perinatal Epidemiology
|May 20, 2025
Summary
Paternal cardiometabolic conditions like hypertension and diabetes are linked to higher offspring perinatal mortality. This highlights the father's biological role in fetal development, with stronger associations observed in male infants.
Area of Science:
- Reproductive Health
- Public Health
- Genetics
Background:
- Paternal cardiometabolic conditions may increase offspring perinatal mortality risk.
- This association requires further investigation due to limited existing research.
Purpose of the Study:
- To investigate the association between fathers' cardiometabolic conditions and offspring perinatal mortality.
- Utilized linked data from Norwegian national health registries.
Main Methods:
- Population-based cohort study using linked Norwegian registries (MBRN, Norwegian Patient Registry, Norwegian Prescription Database).
- Defined paternal exposures: hypertension, diabetes, dyslipidemia, severe obesity.
- Perinatal mortality included fetal deaths (≥16 weeks gestation) and neonatal deaths (first month).
- Multilevel random-intercept Poisson regression models were employed.
Main Results:
- Infants born to fathers with hypertension had a 29% higher risk of perinatal mortality.
- Paternal diabetes and severe obesity also suggested increased perinatal mortality risk.
- Associations were stronger in male offspring compared to female offspring.
Conclusions:
- Increased perinatal mortality in offspring of fathers with cardiometabolic conditions underscores the father's biological role in fetal and placental development.
- Further research is needed to explore the impact of offspring sex on these associations.
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