Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 22, 2025

Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

7.5K

Functional Outcomes in Patients With Prostate Cancer Undergoing Frozen Section Guided Radical Prostatectomy.

Moritz J Reike1, Karl H Tully1, Maximilian Schulmeier1

  • 1Department of Urology, Marien Hospital Herne, Ruhr-University Bochum, Bochum, Germany.

International Journal of Urology : Official Journal of the Japanese Urological Association
|May 20, 2025
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

S2k Guideline Diagnosis and Assessment of Lung Disease Caused by Occupational Silica Dust Exposure (Silicosis) - Clinical Practice Guidelines published by the German Respiratory Society (DGP).

Respiration; international review of thoracic diseases·2026
Same author

Complement mediated thrombotic microangiopathy after liver transplantation in combination with a novel C6 variant of uncertain significance.

Frontiers in immunology·2026
Same author

Impact of Obesity on Systemic Treatment Outcomes in Metastatic Urological Malignancies.

Obesity science & practice·2026
Same author

PSMB8 stratifies therapy response in eosinophilic esophagitis.

Clinical and experimental immunology·2026
Same author

Corrigendum to: "A rare vascular puzzle: Portal hypertension and hepatic lesions" [J Hepatol (2026) 84: e59-61].

Journal of hepatology·2026
Same author

PROTECTOR / FIRE‑10: study protocol for a prospective, randomized, open-label, multicenter phase III trial to investigate the efficacy of preoperative systemic therapy in advanced colon cancer.

BMC cancer·2026
Same journal

Nocturia Beyond the Bladder: Editorial Comment on Kira et al.'s Nationwide JaCS 2023 Analysis.

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Editorial Comment to "Bayesian Multi-Criteria Decision Analysis of Net Clinical Benefit in ARASENS: Overall and Japanese Subgroup Results".

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Comparative Analysis of 3-Year Reintervention Rates for Rezum vs. UroLift: A TriNetX Study.

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Long-Term Oncologic Outcomes After Laparoscopic Radical Nephroureterectomy: A Contemporary Analysis From a Japanese Multicenter Cohort.

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Real-World Outcomes and Prognostic Factors of Immune Checkpoint Inhibitor Rechallenge for Metastatic Renal Cell Carcinoma: A Multicenter Study.

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Outcomes of Gemcitabine, Oxaliplatin, and Paclitaxel Salvage Chemotherapy in Japanese Patients With Relapsed or Refractory Germ Cell Tumors.

International journal of urology : official journal of the Japanese Urological Association·2026
See all related articles
This summary is machine-generated.

Frozen section (FS) enabled nerve-sparing radical prostatectomy (RP) for intermediate-risk prostate cancer (PCa) patients, improving eligibility for this oncologically safe procedure. Outcomes for continence and potency remained comparable between risk groups.

Area of Science:

  • Urology
  • Surgical Oncology
  • Pathology

Background:

  • Nerve-sparing radical prostatectomy (NS-RP) is not routinely offered to intermediate-risk prostate cancer (PCa) patients.
  • Whole surface frozen section (FS) has emerged as a method to ensure oncological safety during NS-RP.
  • The impact of FS on NS during RP and subsequent functional outcomes requires assessment.

Purpose of the Study:

  • To evaluate the effect of implementing FS on nerve-sparing (NS) during radical prostatectomy (RP).
  • To assess the potential for improved functional outcomes, specifically continence and potency, following NS-RP with FS.
  • To determine if FS expands NS eligibility to intermediate-risk PCa patients.

Main Methods:

  • Prospective collection of institutional data from patients with intermediate-risk PCa (PSA ≤ 20 ng/mL, Gleason Score ≤ 7, cT1c-cT2c) undergoing RP.
Keywords:
continencefrozen sectionpotencyprostate cancerradical prostatectomy

More Related Videos

Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser
07:17

Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser

Published on: May 9, 2018

7.9K
Focal Laser Ablation of Prostate Cancer: An Office Procedure
11:07

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

7.6K

Related Experiment Videos

Last Updated: May 22, 2025

Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

7.5K
Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser
07:17

Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser

Published on: May 9, 2018

7.9K
Focal Laser Ablation of Prostate Cancer: An Office Procedure
11:07

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

7.6K
  • Surgeon's decision for NS was guided by intraoperative FS analysis.
  • Potency was assessed using the International Index of Erectile Function (IIEF-5) score (≥ 17), and continence was defined as ≤ 1 pad per day.
  • Multivariable regression analyses were used to identify predictors for potency and continence.

    • Main Results:

    • Of 702 patients, 671 (95.6%) underwent final NS-RP, with FS enabling NS in 666 (95%) cases.
    • Before FS, only 56% of patients would have been candidates for NS-RP.
    • No significant differences in continence (84.1% vs. 82.6%) or potency (p=0.646) were observed between low- and intermediate-risk groups.
    • Higher surgeon volume was significantly associated with improved continence (OR 3.69) and erectile function (OR 2.49).

    Conclusions:

    • The introduction of FS significantly expanded eligibility for NS-RP to include intermediate-risk PCa patients.
    • FS facilitates oncologically safe NS during RP, potentially improving functional outcomes for a broader patient population.
    • Surgeon experience is a critical factor in achieving favorable functional outcomes after NS-RP.