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Transcriptomic Vascular and Endothelial Changes in Experimental Periodontitis in Nonhuman Primates.

L M Nguyen1, O A Gonzalez2,3, A Balian1

  • 1Department of Biomedical Sciences, School of Dental Medicine, University of Nevada Las Vegas, Las Vegas, Nevada, USA.

Oral Diseases
|May 20, 2025
PubMed
Summary
This summary is machine-generated.

Periodontal disease significantly alters blood vessel gene expression, especially during early stages. These vascular changes in the gums contribute to the ongoing inflammation characteristic of this condition.

Keywords:
endotheliumnonhuman primatesperiodontitisvasculature

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Area of Science:

  • Periodontal disease research
  • Vascular biology
  • Transcriptomics

Background:

  • The molecular mechanisms underlying periodontal vasculature changes during disease progression are not fully understood.
  • Periodontal lesions involve alterations in blood vessel integrity and function.

Purpose of the Study:

  • To investigate transcriptomic changes in periodontal vasculature during disease initiation and progression.
  • To identify molecular pathways and bacterial correlations involved in periodontal vascular alterations.

Main Methods:

  • Utilized a nonhuman primate model of experimental ligature-induced periodontitis.
  • Analyzed transcriptomic responses related to vasculature and endothelial cell activities across the lifespan.
  • Correlated gene expression changes with specific bacterial species.

Main Results:

  • Identified age-related effects on angiogenesis and growth factor signaling pathways in healthy tissues.
  • Observed significant alterations in vascular/endothelial gene expression during disease initiation and progression.
  • Found strong correlations between specific bacteria (e.g., P. gingivalis) and changes in vascular genes (e.g., CCL2, TGFB2).
  • Determined that the disease process is the primary driver of vascular/endothelial cell transcriptome changes.

Conclusions:

  • Vascular and endothelial cell processes change with age and are further altered during periodontal disease.
  • Significant vascular changes in gingival tissues contribute to the persistent inflammation seen in periodontitis.
  • Transcriptomic profiling reveals key molecular events in periodontal vasculature during disease development.