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QTc Interval Dispersion in Pediatric Epilepsy: A Case-Control Study From Iran

Ahmad Talebian1, Ali Mohammad Shakiba1, Adele Malekipoor2

  • 1Department of Pediatrics, Kashan University of Medical Sciences, Kashan, Iran.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|May 20, 2025
PubMed

Insights

Children with epilepsy under five years old showed higher QT interval corrected dispersion (QTcd), while those on antiepileptic drugs had lower QTcd. These findings highlight cardiac monitoring needs in pediatric epilepsy.

Area of Science:

  • Cardiology
  • Neurology
  • Pediatrics

Background:

  • QT interval corrected dispersion (QTcd) assesses ventricular repolarization heterogeneity and arrhythmic risk.
  • QTcd is implicated in various neurologic and cardiac conditions.
  • Pediatric epilepsy presents potential cardiac risks requiring investigation.

Purpose of the Study:

  • To compare QTcd in children with epilepsy versus healthy controls.
  • To investigate the influence of age and antiepileptic drug (AED) use on QTcd in pediatric epilepsy.

Main Methods:

  • A case-control study involving 50 children with epilepsy and 50 matched controls.
  • Manual measurement of QTcd from 12-lead electrocardiograms (ECGs).
  • Statistical analysis using SPSS version 22.

Main Results:

  • No significant overall difference in QTcd between children with epilepsy and controls.
  • Significantly higher QTcd in epileptic children under five years old compared to controls.
  • Significantly lower QTcd in epileptic children on AEDs versus those not on treatment.

Conclusions:

  • While overall QTcd did not differ, age (under five) and AED use significantly impact QTcd in pediatric epilepsy.
  • Findings underscore the importance of cardiac evaluation in young epilepsy patients.
  • Early cardiac assessment and intervention are crucial for children with epilepsy.
Abstract

Keywords:
KashanQTc dispersionchildepilepsy

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