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Updated: May 22, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Neoadjuvant Intralesional Methotrexate for Infiltrating Squamous Cell Carcinoma of the Head: A Case Series of 19
Caterina Mariarosaria Giorgio1, Gaetano Licata2, Eugenia Veronica Di Brizzi1
1Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Abstract:
Squamous cell carcinoma (SCC) of the head presents a significant challenge in achieving complete surgical excision while preserving function and aesthetics. Neoadjuvant intralesional methotrexate (MTX) has emerged as a potential strategy to reduce tumour burden preoperatively, facilitating more conservative surgical excisions. The results demonstrated significant lesion shrinkage, with a mean tumour size reduction of 68%, enabling less invasive surgical interventions.
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