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Updated: Jun 16, 2025
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Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein
Nicole L Inniss1,2, George Minasov1,2, Changsoo Chang2,3,4
1Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Abstract:
Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.
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