Related Experiment Video
Updated: May 22, 2025
Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
Published on: July 23, 2016
Functionalized liposomes for intranasal levodopa delivery to the brain
Daria S Gordeeva1, Achraf Sym Tameloucht1, Irina I Semina2
1Institute of Pharmacy, Kazan State Medical University, Kazan, Russian Federation.
Objective:
The study evaluated functionalized liposomes as potential carriers for intranasal delivery of levodopa.
Methods:
Lipid film hydration method was used to obtain conventional and functionalized liposomes with polyethylene glycol or maleimide-PEG. The liposome structure was analyzed by dynamic light scattering and 1H-NMR spectroscopy. Isolated sheep nasal mucosa was used for mucoadhesion and mucous penetration studies. Levodopa release was assessed using a Franz diffusion cell. In vivo experiments were conducted using a method based on the inhibition of dopaminergic transmission.
Results:
The average liposome diameter was 81-91 ± 1 nm. The Pdi was less than 0.300. The zeta potential was negative. An increase in the molar weight of polyethylene glycol in the liposome structure improved mucosa penetration to 0.4 mm. The presence of maleimide did not affect the mucoadhesive properties. The levodopa release profile corresponded to Fickian diffusion. Intranasal administration of levodopa in vivo caused dopaminergic transmission inhibition in rats after 1 h.
Conclusion:
According to the received results, functionalized liposomes are promising for further evaluation as intranasal drug carriers.
Related Concept Videos
01:29Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
01:22Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...