Related Experiment Video

Updated: Jun 25, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

18.7K

18 FDG PET/MRI in Histiocytic Sarcoma of the Spinal Canal

Kohei Hirota1, Feibi Zeng1, Junko Inoue Inukai1

  • 1Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.

Clinical Nuclear Medicine
|May 20, 2025
PubMed

Insights

This study reports a rare case of histiocytic sarcoma involving the central nervous system. Positron emission tomography/magnetic resonance imaging (PET/MRI) effectively evaluated lesion extent and treatment response.

Area of Science:

  • Oncology
  • Neurology
  • Radiology

Background:

  • Histiocytic sarcoma is a rare malignant neoplasm of mature histiocytes.
  • Central nervous system involvement by histiocytic sarcoma is exceptionally uncommon.
  • Accurate staging and treatment monitoring are crucial for managing this rare malignancy.

Purpose of the Study:

  • To report a rare case of histiocytic sarcoma with central nervous system involvement.
  • To illustrate the utility of 18F-FDG PET/MRI in diagnosing and monitoring histiocytic sarcoma.
  • To demonstrate the role of PET/MRI in assessing treatment response during chemotherapy.

Main Methods:

  • A 49-year-old male patient with a lumbar spinal canal mass underwent 18F-FDG PET/MRI.
  • Histopathological examination of the spinal lesion confirmed histiocytic sarcoma.
  • Serial 18F-FDG PET/MRI scans were performed to evaluate changes during chemotherapy.

Main Results:

  • 18F-FDG PET/MRI revealed intense FDG uptake in the primary spinal mass.
  • Metastatic lesions were identified in the cerebellopontine angle and cervical lymph nodes.
  • Changes in FDG uptake on PET/MRI correlated with treatment response during chemotherapy.

Conclusions:

  • 18F-FDG PET/MRI is a valuable tool for evaluating the extent of histiocytic sarcoma.
  • PET/MRI demonstrates efficacy in monitoring treatment response for histiocytic sarcoma.
  • This case underscores the importance of advanced imaging in rare oncological conditions.
Keywords:
MRIPETcentral nervous systemhistiocytic sarcomaspinal canal

More Related Videos

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

10.7K
Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography09:41

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

Published on: January 20, 2023

1.7K

Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...