Related Experiment Video
Updated: May 22, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
The Role of Glucagon-Like Peptide-1 Receptor Agonists in Alcohol Use Disorder
Sadaf Khan1,2, Pavani Sayana3, Sarah Waseem4
1PPD, Part of Thermo Fisher, Cypress, Texas.
Abstract:
Importance: Alcohol use disorder (AUD) is a critical health condition that increases the risk of a variety of social and physical health impairments. Glucagon-like peptide-1 (GLP-1) receptor agonists are potentially effective in reward system-related disorders. The use of GLP-1 receptor agonists has been shown to decrease overall consumption of alcohol in AUD in addition to managing obesity and weight loss. The main objective of this narrative review was to examine the potential benefits, dosages, and mechanisms of GLP-1 receptor agonists on alcohol consumption and how they can potentially modify alcohol-seeking behavior.
Abstract:
Observations: The principal observation included the effect of GLP-1 receptor agonists on the mesolimbic pathways in the central nervous system, the central amygdala, and the GABAergic neurons in the central nervous system. Current research also focuses on the use of GLP-1 receptor agonists in improving glycemic control and reduction of obesity.
Abstract:
Conclusions and Relevance: Clinically, GLP-1 receptor agonists can be potentially used as an adjunct to the treatment of AUD in patients with a body mass index >30 kg/m2 and in those with AUD who have coexisting diabetes mellitus. As decreasing glucose levels and alcohol-seeking behavior are 2 dual effects of the GLP-1 receptor agonists, the dosage can be adjusted accordingly to achieve the desired benefits while reducing the potential side effects of the drug class.
Abstract:
Prim Care Companion CNS Disord 2025;27(3):24nr03855.
Abstract:
Author affiliations are listed at the end of this article.
More Related Videos
07:50A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
Published on: January 29, 2017
07:31Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Related Concept Videos
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
CNS Depressants: Alcohol and Nicotine
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Hypoglycemia and Glucagon
Oral Hypoglycemic Agents: Biguanides and Glitazones
Dipeptidyl Peptidase 4 Inhibitors