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Peristomal Localized Pemphigoid: Is It an Underdiagnosed Condition with a Good Prognosis?
Can Baykal1, Elizaveta Melnicova Ayas, Tuğba Atcı
1Can Baykal, MD, is Professor, Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey; Elizaveta Melnicova Ayas, MD, is Resident; Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey; Tuğba Atcı, MD, is Assistant Professor; Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey; Şule Öztürk Sarı, MD, is Associate Professor, Department of Pathology; Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey; and Nesimi Büyükbabani, MD, is Professor, Department of Pathology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey and Koç Medical Faculty, Istanbul,; and Rıfkiye Küçükoğlu, MD, is Professor, Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Peristomal bullous pemphigoid (BP) involvement is rare, affecting 1.5% of patients. Early recognition of these lesions is crucial for accurate diagnosis and favorable outcomes, differentiating it from irritant dermatosis.
Area of Science:
- Dermatology
- Autoimmune Blistering Diseases
Background:
- Bullous pemphigoid (BP) is an autoimmune blistering disease.
- Peristomal skin involvement in BP is uncommon but can be challenging to diagnose.
Purpose of the Study:
- To determine the incidence of peristomal involvement in bullous pemphigoid.
- To analyze the clinical characteristics and disease course of patients with peristomal BP.
Main Methods:
- Retrospective analysis of 270 bullous pemphigoid patients.
- Evaluation of demographics, stoma details, treatment, and follow-up.
- Comparison with existing literature data.
Main Results:
- Peristomal involvement observed in 1.5% (4/270) of BP patients.
- Lesions appeared a mean of 4.7 years post-stoma placement.
- Three patients had isolated peristomal lesions; one had generalized then localized disease.
Conclusions:
- Peristomal BP may be misdiagnosed as irritant dermatosis.
- Peristomal lesions can be an initial presentation or recurrence of BP.
- Peristomal BP has a favorable prognosis compared to classical BP.
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