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Rare infantile sepsis and meningitis caused by Pasteurella multocida: A case report

Ming-Ming Ni1, Wen-Xin Lin2, Yang Li2

  • 1Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.

Journal of Infection and Public Health
|May 20, 2025
PubMed

Insights

A rare Pasteurella multocida meningitis case in an infant was diagnosed using next-generation sequencing (NGS). This advanced technique identified antibiotic resistance, guiding personalized treatment for this challenging infection.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Genomic Medicine

Background:

  • Pasteurella multocida is a zoonotic bacterium that can cause serious infections.
  • Meningitis and subdural empyema are severe complications, particularly in infants.
  • Early and accurate diagnosis is crucial for effective treatment and improved outcomes.

Observation:

  • A 2-month-old infant presented with symptoms suggestive of meningitis.
  • Standard bacterial cultures were negative, posing a diagnostic challenge.
  • Next-generation sequencing (NGS) was employed for pathogen identification.

Findings:

  • Next-generation sequencing (NGS) successfully identified Pasteurella multocida as the causative agent.
  • The identified strain showed predicted resistance to meropenem and ampicillin.
  • A potential transmission route from a neighbor's dog was identified.

Implications:

  • This case highlights the utility of NGS in diagnosing rare infections when conventional methods fail.
  • It emphasizes the need for personalized antimicrobial therapy based on pathogen resistance profiles.
  • Understanding zoonotic transmission routes is vital for preventing and managing pediatric infections.
Keywords:
InfantInfectionMeningitisPasteurella multocida

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