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Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks
Published on: December 2, 2022
Chemical Constituents of Deep-Sea Derived Fungus Pseudogymnoascus hyalinus and Their Ferroptosis Inhibitory Activity
You Li1,2, Zheng-Biao Zou3, Yan Li4
1College of Marine Living Resource Sciences and Management, Shanghai Ocean University, Shanghai, China.
Abstract:
Four new polyketides including one indanone (1), one isobenzofuranone (2), and two naphthoquinones (3 and 4) were isolated from the deep-sea-derived fungus Pseudogymnoascus hyalinus, along with 20 known compounds (5-24). The structures of new compounds were established by comprehensive analyses of their 1D and 2D NMR, HRESIMS, as well as TD-DFT-ECD. Compounds 5, 6, and 10 displayed potent inhibitory effects against RSL3 induced ferroptosis with EC50 values of 4.74, 1.55, and 3.72 µM, respectively.
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