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Updated: May 22, 2025

Isolation and Characterization of Intact Phycobilisome in Cyanobacteria
Published on: November 10, 2021
What would a hypothetical supercyanobacterium look like?
Ondrej Pencik1, Martina Kolackova2, Katarina Molnarova2
1Department of Chemistry and Biochemistry, Mendel University in Brno, Zemědělská 1665/1, 613 00, Brno, Czech Republic; Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Palackého třída 1946/1, 61200, Brno, Czech Republic.
Abstract:
Over the past two decades, advances in molecular and microbiological methods have broadened the range of microorganisms used in biotechnology. Among them, phototrophic bacteria - especially cyanobacteria - are gaining attention for their potential in tackling climate change and producing biopharmaceuticals. While traditional strains such as Escherichia coli and Bacillus subtilis dominate the field, cyanobacteria offer unique features that present both challenges and opportunities, such as complex gene regulation linked to photosynthesis and carbon fixation, protein sorting, and secretion, as well as the ability to establish novel symbiotic partnerships. This review highlights key developments in engineering cyanobacteria and outlines a vision for a future 'supercyanobacterium' that combines the best traits of current strains, unlocking new possibilities in heterotrophy-dominated biotechnology.
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