Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcranial vibrotactile stimulation enhances hippocampal cholinergic signaling and memory through frequency-dependent mechanotransduction.

Scientific reports·2026
Same author

Molecular architecture of the human TRPC1/C5 heteromeric channel.

Nature communications·2025
Same author

TRPC1-5-5-5 heteromer as a sodium sensor.

Biochemical and biophysical research communications·2025
Same author

Publisher Correction: hsa-mir-483-3p modulates delayed breast cancer recurrence.

Scientific reports·2025
Same author

Peptide Backbone Editing via Post-Translational O to C Acyl Shift.

Journal of the American Chemical Society·2025
Same author

Extended protective effects of three dimensional cultured human mesenchymal stromal cells in a neuroinflammation model.

World journal of stem cells·2025

Related Experiment Video

Updated: May 23, 2025

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

14.1K

Early, very high-dose, and prolonged vitamin C administration in murine sepsis.

Ok-Hyeon Kim1, Tae Wan Kim2, Hana Kang3

  • 1Department of Anatomy and Cell Biology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Scientific Reports
|May 20, 2025
PubMed
Summary

High-dose, prolonged vitamin C (ascorbic acid) administration improved survival and reduced organ damage in a mouse model of sepsis. Optimal treatment involved 180-360 mg/kg/d for 8 days.

More Related Videos

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

8.9K
Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

3.3K

Related Experiment Videos

Last Updated: May 23, 2025

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

14.1K
Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

8.9K
Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

3.3K

Area of Science:

  • Biomedical Science
  • Pharmacology
  • Critical Care Medicine

Background:

  • Sepsis is a life-threatening condition characterized by organ dysfunction.
  • Organ injuries in sepsis are associated with high mortality rates.
  • Vitamin C (ascorbic acid) has shown potential in managing sepsis-related complications.

Purpose of the Study:

  • To determine the optimal timing, dosage, and duration of vitamin C administration in a murine sepsis model.
  • To evaluate the efficacy of ascorbic acid in improving survival and attenuating organ injuries.
  • To investigate the impact of vitamin C on lung, kidney, and liver function during sepsis.

Main Methods:

  • Murine model of sepsis induced by cecal ligation and puncture (CLP).
  • Administration of ascorbic acid (AscA) at 1 or 6 hours post-CLP.
  • Varying AscA doses (90, 180, 360 mg/kg/d) and durations (4 or 8 days).
  • Assessment of survival rates, organ histology, and inflammatory markers.

Main Results:

  • Significant survival improvement with AscA at 180 or 360 mg/kg/d for 8 days.
  • AscA treatment preserved lung architecture and tight junction proteins.
  • Improved histological changes and reduced biomarker expression in kidneys and livers.
  • No significant benefit observed with 4-day AscA treatment.

Conclusions:

  • Prolonged, high-dose vitamin C administration demonstrates therapeutic potential in sepsis-induced organ injury.
  • Optimal vitamin C treatment strategy involves sustained administration for at least 8 days.
  • Further research is warranted to translate these findings into clinical sepsis management.