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Updated: May 22, 2025

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Cholinergic system in schizophrenia: A systematic review and meta-analysis

Zacharie Saint-Georges1,2, Julia MacDonald3, Roya Al-Khalili1

  • 1The University of Ottawa Institute of Mental Health Research at the Royal, Ottawa, ON, Canada.

Molecular Psychiatry
|May 20, 2025
PubMed
Summary

Schizophrenia is linked to widespread reductions in muscarinic and nicotinic receptors. This systematic review of imaging and post-mortem studies confirms significant decreases in key brain areas, impacting neurotransmission.

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