Fluid management strategies in critically ill patients with ARDS: a narrative review

Hypervolemia is associated with worse outcomes in critically ill patients with acute respiratory distress syndrome (ARDS), with early positive fluid balance linked to longer intensive care unit (ICU) stays, prolonged ventilatory support, and increased mortality risk due to cardiopulmonary complications, lung edema, and extrapulmonary organ dysfunction. However, a restrictive fluid management strategy is associated with hypoperfusion and distal organ dysfunction, including acute renal failure and cognitive impairment. Indeed, fluid administration in patients with ARDS represents a challenge, as it must take into account the underlying condition, such as sepsis or acute brain injury (ABI), where optimal fluid management is a major determinant of disease outcome. In such cases, the approach to fluid administration should be individualized based on hemodynamic and clinical parameters according to the course of the disease. The strategy of "salvage, optimization, stabilization, and de-escalation" can guide fluid administration in the initial therapeutic approach, whereas negative fluid balance with the use of diuretics or renal replacement therapy (RRT) should be the goal once hemodynamic stabilization has been achieved.