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Frequent Positive Patch Test Reactions to Glucosides in Children: A Call for Caution?

Silada Kanokrungsee1,2, Julie Leysen1, Olivier Aerts1

  • 1Department of Dermatology, University Hospital Antwerp (UZA) and Research Group Immunology, INFLA-MED Centre of Excellence, University of Antwerp, Antwerp, Belgium.

Contact Dermatitis
|May 21, 2025
PubMed

Insights

Contact allergy to glucosides like decyl glucoside (DG) and lauryl glucoside (LG) is common in children, with a high positivity rate in patch testing. Careful interpretation is needed, especially in atopic children.

Area of Science:

  • Dermatology
  • Allergology
  • Paediatric Medicine

Background:

  • Alkyl glucosides are widely used surfactants in cosmetics and household products.
  • Limited data exists on glucoside contact allergy specifically within paediatric populations.

Purpose of the Study:

  • To investigate the prevalence and clinical features of contact allergy to glucosides in children.
  • To assess the relevance and characteristics of patch test reactions to decyl glucoside and lauryl glucoside in a paediatric cohort.

Main Methods:

  • Retrospective review of paediatric patients (≤16 years) patch tested for decyl glucoside (DG) and lauryl glucoside (LG).
  • Data collected from January 2018 to December 2024 at Antwerp University Hospital (UZA).

Main Results:

  • Out of 241 children tested for DG, 19.5% showed reactions, with 11.2% positive.
  • Positive reactions to LG were less common (2.7%), often concurrent with DG reactions.
  • Most positive reactions were weak; culprit sources were primarily cosmetics.

Conclusions:

  • Patch test reactions to glucosides are frequent in children, with a high positivity rate.
  • Potential for false-positive reactions exists, particularly in young atopic children.
  • Careful interpretation of patch test results and further investigation are recommended.
Abstract

Keywords:
childrencontact allergycontact dermatitisdecyl glucosideglucosideslauryl glucosidepatch test

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