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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Revealing Solvation within [l(-)-Menthol : Thymol] Deep Eutectic Solvents via Microfluidity Assessment
Anushis Patra1, Shreya Juneja1, Siddharth Pandey1
1Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
The Journal of Physical Chemistry. B
|May 21, 2025
Summary
This study explores deep eutectic solvents (DESs) made from menthol and thymol. These nonpolar DESs provide a homogeneous solvation environment, ideal for chemical synthesis and analysis applications.
Area of Science:
- Physical Chemistry
- Supramolecular Chemistry
- Materials Science
Background:
- Deep eutectic solvents (DESs) offer tunable properties for various applications.
- Nonpolar DESs are desirable for specific chemical processes.
- Understanding solvation behavior in DESs is crucial for their effective use.
Purpose of the Study:
- To investigate the solvation environment of nonpolar deep eutectic solvents (DESs) composed of l(-)-menthol and thymol.
- To evaluate the impact of composition and temperature on the microviscosity and solute dynamics within the (Men : Thy) DES system.
- To assess the homogeneity of the solvation environment using multiple fluorescence probes.
Main Methods:
- Preparation of (Menthol : Thymol) DESs at nine different molar ratios.
- Investigation across a temperature range of 293 to 363 K.
- Utilized intramolecular excimer-forming, fluorescence anisotropy, and fluorescence intensity probes to study microviscosity and solute rotational diffusion.
Main Results:
- Microviscosity (ln η_micro) correlated linearly with bulk viscosity (ln η) across all compositions and temperatures.
- Intramolecular excimer formation rate constants (k_a) adhered to the Stokes-Einstein relationship (k_a vs. T/η).
- Solute rotational diffusion followed the Perrin formulation, indicating a lack of significant microheterogeneity.
Conclusions:
- The (Menthol : Thymol) deep eutectic solvent system provides a homogeneous solubilization environment.
- This homogeneous environment is independent of both DES composition and temperature.
- These findings highlight the potential of nonpolar (Men : Thy) DESs for chemical synthesis and analysis.
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