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Protein-Based Multifunctional Hydrogel Adhesive for Wound Healing.

Kai Zhang1,2,3, Heyuan Sun1,2,3, Yuna Qian2

  • 1School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.

Macromolecular Bioscience
|May 21, 2025
PubMed
Summary

This review explores protein-based hydrogel bioadhesives for advanced wound healing. These materials show promise for tissue repair, addressing limitations in current wound management strategies.

Keywords:
hydrogel bioadhesivesmultifunctionalproteinwound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Wound healing involves complex stages: hemostasis, inflammation, proliferation, and remodeling.
  • Effective wound management requires advanced bioadhesive materials.
  • Hydrogel bioadhesives offer promising properties for wound treatment, but protein-based options are under-explored.

Purpose of the Study:

  • To systematically review the design principles and functions of ideal hydrogel bioadhesives for wound repair.
  • To provide an overview of recent advancements in multifunctional protein-based hydrogel bioadhesives.
  • To evaluate the practical performance and future directions of these biomaterials.

Main Methods:

  • Literature review of protein-based hydrogel bioadhesives for wound healing.
  • Analysis of design principles and essential functions in wound repair.
  • Evaluation of hydrogel performance derived from collagen, silk fibroin, sericin, fibrin, gelatin, keratin, and casein.

Main Results:

  • Protein-based hydrogels exhibit excellent physical properties and biocompatibility for wound healing applications.
  • Various proteins like collagen, silk fibroin, and gelatin are utilized to create advanced hydrogel bioadhesives.
  • These hydrogels demonstrate significant potential in promoting tissue repair and restoring integrity.

Conclusions:

  • Protein-based hydrogel bioadhesives represent a significant advancement in wound healing technology.
  • Further research is needed to overcome challenges and facilitate clinical translation.
  • Continued development aims to enhance the efficacy and application of these biomaterials in comprehensive wound management.