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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
The Diagnostic and Prognostic Value of Circulating miR-126-3p and miR-145-5p in Coronary Artery Calcification Lesions
Weiwei Chen1, Fengwen Cui1, Jiwen Fan1
1Department of Cardiovascular Medicine, China-Japan Union Hospital of Jilin University, Changchun, China.
Insights
Arterial calcification is linked to lower levels of miR-126-3p and miR-145-5p. Low miR-126-3p expression predicts major adverse cardiovascular events (MACEs), suggesting its potential as a biomarker.
Area of Science:
- Cardiovascular Research
- Molecular Biology
- Biomarker Discovery
Background:
- Arterial calcification contributes to major adverse cardiovascular events (MACEs), leading to rehospitalization and poor outcomes.
- Evaluating microRNAs (miRNAs) like miR-126-3p and miR-145-5p is crucial for understanding and managing arterial calcification.
- Identifying reliable biomarkers can improve patient stratification and clinical decision-making.
Purpose of the Study:
- To assess the diagnostic capability of miR-126-3p and miR-145-5p in identifying arterial calcification.
- To determine the prognostic significance of these miRNAs in predicting MACEs.
- To explore the relationship between miRNA levels and cardiovascular risk factors.
Main Methods:
- Quantification of plasma miR-126-3p and miR-145-5p levels via qRT-PCR in 131 patients undergoing coronary artery intervention.
- Comparison of miRNA levels between patients with and without arterial calcification.
- 12-month follow-up of patients with calcification to record MACE incidence and rehospitalizations.
Main Results:
- Patients with arterial calcification exhibited lower plasma levels of miR-126-3p and miR-145-5p compared to controls (p < 0.01).
- Low miR-126-3p expression was associated with an increased likelihood of MACEs within 12 months (p < 0.05).
- MACEs group showed lower HDL-C and higher neutrophil ratio.
Conclusions:
- Circulating miR-126-3p and miR-145-5p possess diagnostic utility for arterial calcification.
- miR-126-3p can serve as a valuable blood-based biomarker for predicting MACE risk.
- These miRNAs represent promising targets for future cardiovascular research and therapeutic strategies.
Background:
Arterial calcification and its associated major adverse cardiovascular events (MACEs) are significant contributors to rehospitalization and poor clinical outcomes. This study aims to evaluate the diagnostic utility of miR-126-3p and miR-145-5p in detecting arterial calcification, as well as their prognostic value in predicting the occurrence of MACEs.
Methods:
A total of 131 patients who underwent coronary artery intervention and intravascular imaging were enrolled. Among them, 88 were diagnosed with arterial calcification, while 33 showed no evidence of calcification. Plasma levels of miR-126-3p and miR-145-5p were quantified using qRT-PCR. Clinical and demographic data were also collected to identify potential risk factors with calcification. Patients with calcified lesions were followed for 12 months to document the incidence of MACEs and rehospitalizations, and to evaluate predictors of MACE occurrence.
Results:
Compared to patients without arterial calcification, those with calcification were older, and exhibited significantly lower plasma levels of miR-126-3p and miR-145-5p (p < 0.01). Among patients in the calcification group, those with low miR-126-3p expression [0 (0-0.223), p < 0.05] were more likely to experience MACEs within 12 months. Additionally, in the MACEs group, HDL-C levels were lower [0.081 (0.009-0.698), p < 0.05], while neutrophil ratio were higher [1.081 (1.022-1.143), p < 0.01].
Conclusion:
Circulating miR-126-3p and miR-145-5p demonstrate diagnostic value for arterial calcification. In particular, miR-126-3p could serve as a blood-based biomarker for predicting the risk of MACEs.
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