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Updated: May 6, 2026
The Measurement and Treatment of Suppression in Amblyopia
Published on: December 15, 2012
Association between suppression scotoma and visual acuity in clinical subgroups of amblyopia: a systematic review
Sri Vidhya1, Divya Sundaresh2, Christy Bobby3
1Department of Allied Health Sciences, MS Ramaiah University of Applied Sciences, Bengaluru, India.
Objective:
This review will examine the association between suppression scotoma and visual acuity in clinical subgroups of amblyopia in humans to determine whether distinct causal factors of amblyopia lead to different suppression characteristics and their association with visual acuity.
Introduction:
Amblyopia is a neurodevelopmental disorder that impairs visual acuity, stereo acuity, and contrast sensitivity in 1 or both eyes due to physiological alterations in the visual pathways. Numerous studies have examined the association between amblyopia and suppression. However, the relationship between suppression size, depth, and visual acuity in amblyopia remains unclear.
Eligibility Criteria:
This review will include randomized controlled trials, cohort studies, case-control studies, and cross-sectional studies, with participants of any age or gender diagnosed with amblyopia and with outcome measures of visual acuity (in LogMAR or Snellen's fraction), suppression size (degree of visual angle), and suppression depth (contrast difference in dichoptic targets).
Methods:
This review will follow the JBI methodology for systematic reviews of etiology and risk. Academic and non-academic databases and gray literature will be searched, including MEDLINE (Ovid), Embase (Ovid), Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science Core Collection, ProQuest Health and Medical Collection, and Google Scholar. Titles and abstracts and, later, full texts of included studies will be screened by 2 independent reviewers. Critical appraisal will be conducted using JBI checklists. Where possible, the studies will be pooled using random effects meta-analysis. If statistical pooling is not possible, the findings will be presented in narrative format, including tables and figures. Certainty of the evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.
Review Registration:
PROSPERO CRD42023479043.
