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Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure

Jialing Tang1, Eddie Tam1, Erfei Song2,3,4

  • 1Department of Biology, York University, Toronto, ON, Canada.

Autophagy Reports
|May 21, 2025
PubMed

Insights

Autophagy and sterile inflammation are key players in heart failure development. Targeting these processes, particularly mitochondrial autophagy, offers promising therapeutic strategies for heart failure patients.

Area of Science:

  • Cardiovascular Research
  • Cellular Biology
  • Immunology

Background:

  • Heart failure is a major cause of death with limited treatment options.
  • Mechanisms driving heart failure, including autophagy and sterile inflammation, are not fully understood.
  • Mitochondria play a role in sterile inflammation via damage-associated molecular patterns (DAMPs).

Purpose of the Study:

  • To review the interplay between autophagy and sterile inflammation in heart failure.
  • To explore the role of mitochondrial autophagy in cardiac function and inflammation.
  • To highlight potential therapeutic targets for heart failure.

Main Methods:

  • Review of preclinical models of heart failure, including ischemia/reperfusion injury and pressure overload.
  • Examination of the literature on autophagy, sterile inflammation, and their crosstalk.
  • Analysis of the role of mitochondria and DAMPs in cardiac pathology.

Main Results:

  • Autophagy has context-dependent roles, being both beneficial and detrimental in heart failure.
  • Sterile inflammation, exacerbated by mitochondrial DAMPs, contributes to heart failure progression.
  • Selective mitochondrial autophagy is crucial for maintaining cardiac function.

Conclusions:

  • The crosstalk between autophagy and sterile inflammation is critical in heart failure pathogenesis.
  • Therapeutic strategies targeting autophagy and sterile inflammation show promise for heart failure.
  • Further research into these pathways could lead to improved cardiometabolic therapeutics.

Keywords:
Autophagyheart failureischaemia/reperfusionpressure overloadsterile inflammation

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