Trends in Research on the P2X7 Receptor: A Bibliometric and Visualization Analysis

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Chao Ren1,2,3,4, Jingjing Zhang5, Ting Yang1,2,3

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, People's Republic of China.

Journal of Inflammation Research
|May 21, 2025
PubMed

Insights

Research on the P2X7 receptor (P2X7R) is growing, with significant contributions from China and the US. Future studies may focus on P2X7R

Area of Science:

  • Immunology
  • Neuroscience
  • Pharmacology

Background:

  • The P2X7 receptor (P2X7R), activated by ATP, plays a crucial role in biological processes, including inflammation and disease pathogenesis.
  • Despite its clinical relevance, comprehensive bibliometric analyses of P2X7R research are limited.

Purpose of the Study:

  • To conduct a bibliometric investigation of P2X7R research.
  • To quantify publication output, identify key contributors, and map geographical distributions.
  • To elucidate current research frontiers and emerging trends in P2X7R studies.

Main Methods:

  • Bibliometric analysis of 4551 articles published since 1985, retrieved from Web of Science using the query "P2X7R".
  • Visualization techniques were employed to represent complex bibliometric relationships.
  • Analysis included publication volume, author contributions, geographical distribution, and thematic mapping.

Main Results:

  • Publication volume shows sustained growth, with 4551 articles by 13,471 authors identified.
  • China leads in quantitative output (1871 articles), while the United States leads in international collaborations.
  • Thematic mapping identified key research areas: "P2X7R, inflammation, microglia" and "P2X7R, apoptosis, purinergic". "P2X7R, P2 receptors, oxidative stress" indicates future development potential.

Conclusions:

  • P2X7R research is expanding and shows increasing interdisciplinary integration.
  • The field is poised for new developments, particularly in areas linking P2X7R with P2 receptors and oxidative stress.
  • Bibliometric analysis provides valuable insights into the landscape and future trajectory of P2X7R research.
Keywords:
P2X7 receptorVOSviewerbibliometrixweb of science

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