[Edema-protective effect of clobenoside]

Intravenous administration of etacrynic acid induces protein rich oedema in hind legs of chloralose anaesthesized cats. Clobenoside was able to prevent the development of this oedema if administered prior to oedema provocation either orally or intravenously. The degree of inhibition of oedema development was quite similar after oral and intravenous administration, respectively, thus the bioavailability of clobenoside should be good. The half-life of orally administered clobenoside is prolonged as even 24 h after a single oral administration the activity was considerably high. Clobenoside did not influence blood pressure nor heart rate and did not produce any direct vasoactive effects.