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Updated: May 23, 2025

Anterior Cervical Discectomy and Fusion in the Ovine Model
Published on: October 5, 2009
Contiguous Two-Level Anterior Cervical Discectomy and Fusion Using Zero-P VA System: A Retrospective Study
Qiang Zhang1, Zhe Chen1, Yazhou Lin1
1Department of Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Short-term findings after two-level anterior cervical discectomy and fusion (ACDF) show high rates of screw loosening and prosthesis subsidence. Screw loosening is a significant risk factor for subsidence, impacting patient outcomes.
Area of Science:
- Spine surgery
- Orthopedic implants
- Radiology
Background:
- Anterior cervical discectomy and fusion (ACDF) is a common procedure for cervical spine pathologies.
- Zero-P VA devices are utilized in ACDF to promote fusion and stability.
- Understanding short-term radiological outcomes is crucial for evaluating implant performance and patient recovery.
Purpose of the Study:
- To investigate short-term radiological findings following contiguous two-level ACDF using Zero-P VA devices.
- To assess the incidence of prosthesis subsidence and screw loosening.
- To identify potential risk factors and their impact on functional outcomes.
Main Methods:
- Retrospective analysis of patients undergoing contiguous two-level ACDF (C3-C7) with Zero-P VA.
- Postoperative assessment at 3 months using anteroposterior and lateral cervical X-rays.
- Evaluation of functional outcomes using Visual Analog Scale (VAS) and Neck Disability Index (NDI).
Main Results:
- High rates of prosthesis subsidence (34.9%) and screw loosening (74.6%) were observed.
- Screw loosening was significantly associated with prosthesis subsidence (p=0.0005).
- Prosthesis subsidence correlated with higher VAS scores, while NDI scores were elevated regardless of screw loosening or subsidence.
Conclusions:
- Contiguous two-level ACDF with Zero-P VA is associated with frequent screw loosening and prosthesis subsidence.
- Screw loosening appears to be a primary risk factor for prosthesis subsidence.
- These findings highlight the need for careful surgical technique and monitoring to mitigate adverse radiological events.
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