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Updated: Jun 17, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
Published on: November 1, 2012
THE BNIP3 TRIAD: MITOCHONDRIA, LYSOSOMES AND INFLAMMATION IN HEALTHY MUSCLE AGING
Andrea Irazoki1,2,3, Antonio Zorzano1,2,3, David Sebastian1,2,3
1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10-12, Barcelona, 08028 Spain.
Abstract:
During aging, skeletal muscle undergoes a loss of mass, strength and function, encompassed in the biological process termed sarcopenia. Given demographic aging, it is essential to comprehend the molecular determinants resulting in age-related sarcopenia. Here we studied the role of the mitophagy adaptor BNIP3 in mitochondrial homeostasis and muscle during aging. Our findings reveal that BNIP3 orchestrates mitochondrial and lysosomal function to mitigate muscle inflammation and atrophy during aging.
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