Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

6.7K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
6.7K
COP Coated Vesicles00:59

COP Coated Vesicles

7.5K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
7.5K
The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

4.3K
In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
4.3K
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

3.0K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
3.0K
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

6.7K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
6.7K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.4K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Industrial robot transmission components cross-machines fault diagnosis via fault intrinsic representation and channel self-healing under sensor failure.

Scientific reports·2026
Same author

Calf circumference as a simple tool versus chest-CT derived skeletal muscle index in assessing osteosarcopenia and one-year outcomes in osteoporotic vertebral fractures.

Aging clinical and experimental research·2026
Same author

Transcriptome Analysis of Differentially Expressed Genes and Molecular Pathways Involved During Osteoclast Differentiation.

Molecular biotechnology·2025
Same author

Curvature-dependent propulsion of elastic flagella.

Soft matter·2025
Same author

Lobetyolin Suppressed Osteoclastogenesis and Alleviated Bone Loss in Ovariectomy-Induced Osteoporosis via Hindering p50/p65 Nuclear Translocation and Downstream NFATc1/c-Fos Expression.

Drug design, development and therapy·2025
Same author

Modified criteria for identifying elevated bone mass.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025

Related Experiment Video

Updated: May 22, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.5K

Magnetically driven lipid vesicles for directed motion and light-triggered cargo release.

Vinit Kumar Malik1, Chih-Tang Liao1,2, Chenghao Xu1

  • 1Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801 USA. jiefeng@illinois.edu.

Nanoscale
|May 21, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed magnetic giant unilamellar vesicles (magGUVs) for targeted drug delivery. These vesicles can be guided by magnetic fields and release contents on demand with light, advancing precision medicine.

More Related Videos

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
08:35

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Published on: February 21, 2014

14.8K
Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients
08:15

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Published on: July 16, 2018

7.9K

Related Experiment Videos

Last Updated: May 22, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.5K
Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
08:35

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Published on: February 21, 2014

14.8K
Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients
08:15

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Published on: July 16, 2018

7.9K

Area of Science:

  • Biotechnology
  • Materials Science
  • Nanomedicine

Background:

  • Targeted drug delivery and precision medicine aim to improve treatment efficacy and reduce side effects.
  • Lipid-based systems are promising for drug delivery due to biocompatibility and versatility.
  • Giant unilamellar vesicles (GUVs) are a potential drug delivery platform, but controlled motion is a challenge.

Purpose of the Study:

  • To investigate the controlled motion of magnetic GUVs (magGUVs) in magnetic fields.
  • To develop and validate a simulation model for magGUV propulsion.
  • To demonstrate a system for directed magGUV motion and light-induced content release.

Main Methods:

  • Experimental studies of magGUVs in inhomogeneous magnetic fields.
  • Development of a lattice Boltzmann simulation for GUV propulsion.
  • Proof-of-concept for directed motion and light-triggered release.

Main Results:

  • Systematic investigation of magGUV motion under magnetic fields.
  • Comparison of experimental speeds with lattice Boltzmann simulations.
  • Demonstration of controlled navigation and localized drug release via light.

Conclusions:

  • This study provides a foundation for developing lipid-based drug delivery vehicles with navigational control.
  • The research advances targeted therapeutic strategies in precision medicine.
  • Combining directed motion with on-demand release capabilities is key for future drug delivery systems.