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Pain as an Adverse Event During Chemotherapy in Children with Acute Lymphoblastic Leukemia: A Cross-Sectional

Fernanda Machado Silva-Rodrigues1, Pamela S Hinds2, Carlos Alberto Scrideli3

  • 1Department of Maternal-Infant and Psychiatric Nursing, School of Nursing, University of São Paulo, São Paulo - SP, Brazil.

Cancer Control : Journal of the Moffitt Cancer Center
|May 21, 2025
PubMed

Insights

Pediatric cancer patients experiencing pain during chemotherapy often face longer hospital stays. This study highlights the need to address pain to improve quality of life and treatment outcomes for children with Acute Lymphoblastic Leukemia (ALL).

Area of Science:

  • Pediatric Oncology
  • Pain Management
  • Hematology

Background:

  • Pain is a frequent chemotherapy side effect in pediatric cancer patients.
  • Understanding pain's impact is crucial for enhancing quality of life and treatment efficacy.
  • Children with Acute Lymphoblastic Leukemia (ALL) are particularly susceptible to chemotherapy-induced pain.

Purpose of the Study:

  • To characterize pain in pediatric patients with Acute Lymphoblastic Leukemia (ALL).
  • To investigate the relationship between pain, hospitalization duration, and relapse.
  • To explore the influence of age, gender, and risk level on pain experiences.

Main Methods:

  • Retrospective analysis of 610 patient observations from the Brazilian GBTLI-99 protocol.
  • Pain assessment using Common Terminology Criteria for Adverse Events (CTCAE).
  • Statistical analysis including Chi-square, Mann-Whitney, Poisson, and logistic regression models.

Main Results:

  • Patients experiencing pain had significantly longer hospitalization durations.
  • No significant gender-based differences were found in the presence of pain.
  • Further analysis explored associations with age, risk level, and relapse.

Conclusions:

  • Pain is a significant factor associated with prolonged hospitalization in pediatric ALL patients.
  • This study underscores the importance of managing pain as a critical event impacting patient outcomes.
  • Findings provide a foundation for improving supportive care and treatment response in Brazilian pediatric cancer patients.

Keywords:
cancerchemotherapychildrenpain

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