Related Experiment Video
Updated: May 22, 2025

Repeated Orotracheal Intubation in Mice
Published on: March 27, 2020
Dynamic Airway CT for Morphometric Analysis of Pediatric Tracheomalacia Throughout Respiration
Hannah F Case1,2, Michael Bindschadler3, Michael Barbour3,4
1Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Abstract:
Dynamic airway computed topography (4D-CT) can be used to evaluate the trachea in pediatric patients with tracheomalacia. The 4D-CT enables objective and quantitative evaluation throughout all phases of respiration; however, current systems focus on qualitative review of generated 4D images. Few analytic workflows are available to assist in the extraction of the quantitative geomorphic data generated. In this study, we share a protocol developed within the 3D Slicer framework that performs semi-automatic tracheal segmentation and subsequent geomorphic analysis. This methodology is applied to 4 sample cases with varying degrees of tracheal collapse throughout all phases of respiration to demonstrate output of cross-sectional area, aspect ratio (defined as the ratio between minor-to-major luminal axis lengths), and tracheal volume (bound by the subglottis and carina) metrics.
Related Concept Videos
Trachea
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
Physical Assessment of the Respiratory Tract II: Inspection
Chest Configuration
The chest configuration...
Assessment of Airway, Skin Color, and Use of Accessory Muscles
Introduction
The initial evaluation of a patient's respiratory system...
Physical Assessment of the Respiratory Tract I: Health History
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and...
Respiratory Volumes
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Anatomy of Respiratory System II: Lower Respiratory Tract
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...

