Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Polyneuropathy after cisplatin treatment].

C Meier, A Goldhirsch, C Hess

    Deutsche Medizinische Wochenschrift (1946)
    |May 3, 1985
    PubMed
    Summary

    Cis-platinum chemotherapy for ovarian cancer can cause peripheral neuropathy, primarily affecting sensory functions like vibratory perception. Motor function remains largely unaffected, with limited recovery observed in some patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Final outcomes of the SOFT and TEXT phase III trials in premenopausal hormone receptor-positive early breast cancer.

    Annals of oncology : official journal of the European Society for Medical Oncology·2026
    Same author

    Genomic characterisation of hormone receptor-positive breast cancer arising in very young women.

    Annals of oncology : official journal of the European Society for Medical Oncology·2023
    Same author

    Moderate penetrance genes complicate genetic testing for breast cancer diagnosis: ATM, CHEK2, BARD1 and RAD51D.

    Breast (Edinburgh, Scotland)·2022
    Same author

    Continuous versus intermittent extended adjuvant letrozole for breast cancer: final results of randomized phase III SOLE (Study of Letrozole Extension) and SOLE Estrogen Substudy.

    Annals of oncology : official journal of the European Society for Medical Oncology·2021
    Same author

    Reply to Does the expert panel at the St Gallen meeting provide an unbiased opinion about the management of women with early breast cancer?

    Annals of oncology : official journal of the European Society for Medical Oncology·2020
    Same author

    International consensus on treatment of early breast cancer: radiotherapy issues A response to 'International expert consensus on radiotherapy of early breast cancer'.

    Annals of oncology : official journal of the European Society for Medical Oncology·2020

    Area of Science:

    • Neurology
    • Oncology
    • Pharmacology

    Context:

    • Ovarian carcinoma treatment often involves platinum-based chemotherapy.
    • Cis-platinum is a widely used chemotherapeutic agent.

    Purpose:

    • To investigate the incidence and characteristics of polyneuropathy in women treated with cis-platinum for ovarian carcinoma.
    • To evaluate the neurophysiological and histopathological findings associated with cis-platinum-induced neuropathy.

    Summary:

    • Polyneuropathy developed in 7 of 87 women treated with cis-platinum for ovarian carcinoma.
    • Distal sensory disturbances (vibratory perception, acrognosis) were prominent, with no significant motor dysfunction observed.
    • Sural nerve biopsies showed primary axonal degeneration, affecting large-diameter myelinated fibers. Limited functional recovery was noted during follow-up.

    Related Experiment Videos

    Impact:

    • Highlights the risk of sensory polyneuropathy with cis-platinum chemotherapy.
    • Informs clinical monitoring and management of chemotherapy-induced neurological side effects.
    • Contributes to understanding the neurotoxic mechanisms of cis-platinum.