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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

176
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
176
Infertility in Females01:28

Infertility in Females

253
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
253

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Updated: May 22, 2025

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts
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Early Pregnancy Loss Rate in In Vitro Fertilization Versus Non-IVF Pregnancies.

Peter M Doubilet1, Carol B Benson1, Elizabeth S Ginsburg2

  • 1Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|May 21, 2025
PubMed
Summary

In vitro fertilization (IVF) does not independently increase early pregnancy loss risk. Women undergoing IVF have the same miscarriage likelihood as those conceiving naturally when other factors are considered.

Keywords:
early pregnancy lossfirst trimesterin vitro fertilization

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Area of Science:

  • Reproductive Medicine
  • Obstetrics
  • Perinatology

Background:

  • Early pregnancy loss (EPL) is a significant concern in assisted reproductive technologies.
  • Understanding the independent impact of in vitro fertilization (IVF) on EPL is crucial for patient counseling and clinical practice.

Purpose of the Study:

  • To compare EPL rates between in vitro fertilization (IVF) and non-IVF pregnancies.
  • To determine if IVF has an independent effect on first-trimester pregnancy outcomes, controlling for maternal age and vaginal bleeding.

Main Methods:

  • Retrospective analysis of 16,458 singleton intrauterine pregnancies with known first-trimester outcomes over 30 years.
  • Assessment of EPL rates based on mode of conception (IVF vs. non-IVF), maternal age, vaginal bleeding, and ultrasound findings.
  • Logistic regression analysis to evaluate the independent effect of IVF on EPL, adjusting for confounders.

Main Results:

  • The overall EPL rate was 20.3%.
  • IVF pregnancies, advanced maternal age (≥35 years), and vaginal bleeding were associated with higher EPL rates (P < .001).
  • Logistic regression revealed that mode of conception (IVF vs. non-IVF) had no independent effect on EPL (P = .33 for yolk sac only, P = .30 for embryo).

Conclusions:

  • In vitro fertilization (IVF) does not independently impact first-trimester pregnancy outcomes.
  • The likelihood of miscarriage in IVF pregnancies is comparable to non-IVF pregnancies when controlling for maternal age and vaginal bleeding.