Pharmacological interventions and myocardial infarct size in rat

Infarction was produced in male albino rats by left coronary artery ligation and infarct size was measured using NBT staining. Imidazole significantly decreased the myocardial infarct. The effect did not appear to be mediated through the thromboxane synthetase inhibitory property of imidazole because dazoxiben (a selective thromboxane synthetase inhibitor) failed to produce a similar effect. Propranolol pretreatment decreased the infarct size but treatment after coronary ligation increased it. Reserpine treatment did not alter the infarct size significantly.