Associations of sarcopenia, sarcopenia components and sarcopenic obesity with cancer incidence: A prospective cohort study of 414,094 participants in UK Biobank
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View abstract on PubMed
Summary
This summary is machine-generated.Sarcopenia, characterized by low muscle strength and mass, is linked to increased cancer risk, particularly liver, blood, and colorectal cancers in males. Early identification of sarcopenia components may aid cancer prevention efforts.
Area Of Science
- Gerontology
- Oncology
- Epidemiology
Background
- Sarcopenia, a condition defined by reduced muscle strength, mass, and physical performance, is a growing concern in aging populations.
- Understanding the relationship between sarcopenia and cancer incidence is crucial for public health strategies.
Purpose Of The Study
- To investigate the association between sarcopenia, its components, and the incidence of various cancers.
- To explore potential sex differences in these associations.
Main Methods
- A prospective cohort study utilizing UK Biobank data from 414,094 participants.
- Sarcopenia and its components were defined using the EWGSOP2 2019 criteria.
- Cox proportional hazard models were employed, adjusting for multiple confounding factors.
Main Results
- Sarcopenia was associated with a higher risk of liver, haematological, and colorectal cancers in males.
- Components of sarcopenia, such as low grip strength and slow walking pace, were linked to increased risks of specific cancers.
- Sarcopenic obesity was associated with a higher risk of colorectal cancer in males.
Conclusions
- Sarcopenia, its components, and sarcopenic obesity are associated with an increased risk of several cancers, predominantly in males and affecting the gastrointestinal tract.
- Early identification of sarcopenia components may contribute to cancer prevention strategies.
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