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Related Experiment Video

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Analysis of Translation in the Developing Mouse Brain using Polysome Profiling
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A case against purity: prioritizing translational polysubstance use research.

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Preclinical addiction research should incorporate polysubstance use (PSU) patterns, not just single drugs. Including people with lived experience is crucial for developing effective treatments for addiction harms.

Keywords:
individuals with living experiencepolysubstance usepreclinical modelstranslational addiction science

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Area of Science:

  • Neuroscience
  • Addiction Science
  • Translational Research

Background:

  • Preclinical addiction research often models monosubstance use, which does not reflect real-world polysubstance use (PSU).
  • PSU is highly prevalent and involves complex interactions within an evolving illicit drug supply.
  • Current models lack the expertise of people who use drugs, hindering scientific advancement.

Purpose of the Study:

  • To advocate for the integration of clinically relevant PSU patterns into preclinical addiction models.
  • To emphasize the critical role of including people with lived experience as collaborators in translational research.
  • To address the limitations of studying addictive drugs in isolation.

Main Methods:

  • Review and critique of current preclinical addiction research methodologies.
  • Argument for a paradigm shift away from 'purity' in experimental design.
  • Emphasis on incorporating real-world polysubstance use scenarios.

Main Results:

  • Preclinical models frequently fail to mirror the complexity of human substance use disorders.
  • The exclusion of individuals with lived experience limits the scope and applicability of research findings.
  • There is a significant gap in understanding the neurobehavioral underpinnings of PSU.

Conclusions:

  • Preclinical studies of addictive drugs must move beyond monosubstance paradigms to include PSU.
  • Meaningful collaboration with people with lived experience is essential for developing effective addiction therapeutics.
  • Further research is needed across the translational spectrum to address PSU.