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Association Between Modifiable Lifestyle Factors and Incident Cardiac Conduction Disease

Jiwen Zhong1, Rui Tang2, Liuxin Li3

  • 1Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, Guangdong, China.

JACC. Asia
|May 21, 2025
PubMed

Insights

Excessive alcohol intake, prolonged sedentary time, and long sleep duration increase cardiac conduction disease (CCD) risk. Adopting a healthy lifestyle is key for CCD prevention.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Epidemiology

Background:

  • Modifiable lifestyle factors and their impact on cardiac conduction disease (CCD) remain understudied.
  • Understanding these associations is crucial for developing effective prevention strategies.

Purpose of the Study:

  • To prospectively investigate the relationship between modifiable lifestyle factors and the incidence of cardiac conduction disease (CCD).

Main Methods:

  • Prospective cohort study involving 89,377 participants aged 18-90, free of CCD at baseline.
  • Assessment of lifestyle factors including alcohol consumption, physical activity, sedentary behavior, and sleep duration.
  • Analysis of both baseline and long-term lifestyle patterns in relation to incident CCD.

Main Results:

  • Over 1.2 million person-years of follow-up identified 3,723 cases of CCD.
  • Baseline excessive alcohol consumption (≥5 drinks/day), high sedentary behavior (≥4 hours/day), and long sleep duration (≥9 hours/day) were associated with increased adjusted Hazard Ratios (HRs) for CCD.
  • Chronic adherence to these unhealthy lifestyle factors demonstrated significantly higher adjusted HRs for incident CCD, with values ranging from 1.67 to 2.16.

Conclusions:

  • Excessive alcohol consumption, high sedentary behavior, and prolonged sleep duration are linked to elevated risks of developing cardiac conduction disease (CCD).
  • These findings underscore the importance of a low-risk lifestyle in the primary prevention of CCD.
Abstract

Keywords:
cardiac alcohol consumptionconduction diseaselifestyle factorsnighttime sleep durationsedentary behavior

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