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Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

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Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
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Deciphering the Threshold and Segmented Nonlinear Association Between Systemic Inflammation Response Index and Spinal

Muradil Mardan1, Ze-Yu Lu1, Qing-Yin Xu1

  • 1Spine Center, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Global Spine Journal
|May 21, 2025
PubMed
Summary

The Systemic Immune-Inflammation Index (SIRI) shows a complex link with spinal bone mineral density (BMD). Age, hypertension, and diabetes modify this relationship, suggesting SIRI may indicate osteoporosis risk.

Keywords:
bone healthinflammation biomarkersosteoporosispopulation-based studyspinal bone mineral densitysystemic inflammation response index

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Area of Science:

  • Immunology
  • Gerontology
  • Endocrinology

Background:

  • The Systemic Immune-Inflammation Index (SIRI), derived from neutrophil, monocyte, and lymphocyte counts, is increasingly recognized for its role in systemic inflammation.
  • Bone mineral density (BMD) is a critical indicator of skeletal health, with declines associated with increased fracture risk.

Purpose of the Study:

  • To investigate the association between SIRI and spinal BMD in a large adult population.
  • To evaluate how age, hypertension, and diabetes influence the relationship between SIRI and spinal BMD.

Main Methods:

  • A cross-sectional study analyzed data from 13,950 participants aged 20 years and older.
  • SIRI was calculated from complete blood count data, and spinal BMD was measured using dual-energy X-ray absorptiometry (DXA).
  • Linear regression, generalized additive models, and segmented regression analyses were employed, including subgroup analyses.

Main Results:

  • A threshold effect for SIRI on spinal BMD was identified at 0.68.
  • Below this threshold, SIRI was negatively correlated with spinal BMD (β = -0.0412, P = 0.0494).
  • Above the threshold, SIRI showed a positive correlation with spinal BMD (β = 0.0079, P < 0.0001), with stronger associations observed in older adults and individuals with hypertension or diabetes.

Conclusions:

  • A segmented, nonlinear relationship exists between SIRI and spinal BMD.
  • Age, hypertension, and diabetes significantly modify this association.
  • SIRI may serve as a potential biomarker for assessing osteoporosis risk.