-455A Allele May Be a Protective Locus for Aseptic Lower Extremity Superficial Thrombophlebitis

Objective: We designed a prospective experiment to explore the whole promoter region of fibrinogen B β (FGB) with the intent to detect all single nucleotide polymorphisms (SNPs) in this region and their impact on the susceptibility of aseptic lower extremity superficial thrombophlebitis (STP). Methods: The experiment was conducted prospectively and randomized. Thirty-four idiopathic STP patients and 50 healthy people were recruited, respectively, as case and control groups. The whole FGB promoter was gene sequenced. Results: From upstream to downstream of the promoter, a totally 6 SNPs-rs1800789 (-1420G/A), rs2227389 (-993C/T), rs1800791 (-854G/A), rs1800790 (-455G/A), rs1800788 (-249C/T), and rs1800787 (-148C/T) were detected via gene sequencing. A statistical difference was found in the -455A allele (rs1800790) between the two groups (p < 0.05, odds ratio = 0.368, 95% confidence interval: 0.093 - 0.852), while no statistical difference as for the other five SNPs (all p > 0.05). Conclusions: The 455A allele may be a protective locus for the onset of STP. However, due to the low incidence of idiopathic STP, multiple verification tests are still needed.