Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholinergic agents: antinociception without morphine type dependence in rats.

M Widman, S Tucker, D A Brase

    Life Sciences
    |May 27, 1985
    PubMed
    Summary

    Cholinergic agents like oxotremorine and physostigmine do not cause opiate-like withdrawal symptoms in rats. However, they may reduce the development or signs of morphine dependence and increase mortality.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Opioid-like adverse effects of tianeptine in male rats and mice.

    Psychopharmacology·2022
    Same author

    Restarting plastic surgery: Drawing on the experience of the initial COVID-19 pandemic to inform the safe resumption of services.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2020
    Same author

    A plastic surgery service response to COVID-19 in one of the largest teaching hospitals in Europe.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2020
    Same author

    Remarks on a Case of Extra-Uterine Pregnancy.

    The Medical and physical journal·2018
    Same author

    Isolation of DNA from small amounts of elephant ivory: Sampling the cementum with total demineralization extraction.

    Forensic science international·2018
    Same author

    A feasibility study for a triple-blind randomized controlled trial investigating the effects of oral isotretinoin on mood and quality of life in patients with acne vulgaris.

    Clinical and experimental dermatology·2017

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Addiction Research

    Background:

    • Opiate withdrawal in rats is characterized by predictable body weight loss.
    • Cholinergic drugs are being investigated for their potential role in modulating opiate dependence.

    Purpose of the Study:

    • To investigate whether chronic administration of cholinergic agents (oxotremorine, physostigmine) induces opiate-like withdrawal symptoms.
    • To determine if these cholinergic agents can antagonize the development or manifestation of morphine physical dependence.

    Main Methods:

    • Rats were treated chronically with oxotremorine or physostigmine.
    • Morphine-dependent rats were substituted with saline or cholinergic agents.
    • Rats were infused with morphine combined with cholinergic agents.

    Related Experiment Videos

  • Body weight changes and behavioral signs of withdrawal were monitored.

    • Main Results:

    • Chronic oxotremorine or physostigmine treatment did not cause weight loss or opiate-like withdrawal signs upon cessation.
    • No difference in weight loss was observed between morphine-dependent rats substituted with saline or cholinergic agents.
    • Increased mortality was noted in rats substituted with cholinergic agents compared to saline.
    • Co-infusion of morphine with cholinergic agents resulted in less weight loss but not fewer behavioral signs of withdrawal.

    Conclusions:

    • Cholinergic agents do not induce morphine-like physical dependence independently.
    • Cholinergic agents appear to partially antagonize the development or manifestation of opiate dependence in rats.
    • Further research is warranted to explore the clinical implications of cholinergic agents in managing opiate dependence.