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Metabolic and immune heterogeneity in stroke: Insights into subtype identification and biomarker discovery

Wei Wang1, Qiuyang Qian1, Ziye Guo2

  • 1Rehabilitation Medicine Department, Shenzhen Longhua District People's Hospital, Shenzhen, China.

Plos One
|May 21, 2025
PubMed

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A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...