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Multimodal Web-Based Telerehabilitation for Patients With Post-COVID-19 Condition: Protocol for a Randomized
Aleksandar Tomaskovic1, Vincent Weber1, David T Ochmann1
1Department of Sports Medicine, Prevention and Rehabilitation, Institute of Sport Science, Johannes Gutenberg University Mainz, Mainz, Germany.
JMIR Research Protocols
|May 21, 2025
Summary
This study investigates a multimodal telerehabilitation program for post-COVID-19 condition (PCC). The program aims to improve physical capacity and reduce symptoms in severely affected patients.
Area of Science:
- Rehabilitation Medicine
- Cardiopulmonary Exercise Testing
- Digital Health
Background:
- Post-COVID-19 condition (PCC) presents persistent symptoms like fatigue and cognitive impairment.
- Emerging evidence supports telerehabilitation for improving physical capacity and reducing healthcare costs in PCC patients.
Purpose of the Study:
- To evaluate a multimodal, symptom-titrated telerehabilitation program against standard care for severely affected PCC patients.
- To assess the program's superiority using cardiopulmonary exercise test (CPET) metrics: highest oxygen uptake rate (VO2peak) and minute ventilation/carbon dioxide production slope (VE/VCO2).
- To gain insights into clinical and physiological adaptations in PCC for future rehabilitation strategies.
Main Methods:
- Prospective, randomized, waitlist-controlled trial with 8-week intervention and 8-week follow-up phases.
- Intervention group received a web-based multimodal telerehabilitation program including consultations and therapies.
- Control group received standard care with a single consultation and self-directed pacing.
Main Results:
- Recruitment ongoing, with 80 participants enrolled as of March 2025.
- Data analysis is in progress; baseline data analysis expected by July 2025.
- Final results anticipated by December 2025.
Conclusions:
- This is the first RCT on multimodal, symptom-titrated telerehabilitation for severely affected PCC patients.
- Findings will inform CPET-based diagnostics and personalized rehabilitation strategies for postviral syndromes.
- Results will be disseminated to ensure scientific, clinical, and public impact.
