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Updated: May 23, 2025
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Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
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VISUAL OUTCOMES AND CLINICAL FEATURES OF EXTENSIVE MACULAR ATROPHY WITH PSEUDODRUSEN
Letícia de Oliveira Audi1, Ricardo A P de Carvalho2, Antônio M Casella3
1Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Retina (Philadelphia, Pa.)
|May 21, 2025
Summary
Extensive macular atrophy with pseudodrusen (EMAP) is linked to rheumatic fever complications. Early diagnosis and treatment of rheumatic fever may impact EMAP progression and visual outcomes.
Area of Science:
- Ophthalmology
- Medical Imaging
- Rheumatology
Background:
- Extensive macular atrophy with pseudodrusen (EMAP) is a rare condition.
- Understanding its imaging characteristics and associated risk factors is crucial for patient management.
Purpose of the Study:
- To characterize EMAP using multimodal imaging.
- To identify factors associated with visual loss in EMAP patients.
Main Methods:
- Observational case series of 74 patients diagnosed with EMAP.
- Multimodal imaging including CFP, FAF, and OCT was utilized.
- Statistical analysis (Tobit regression) identified risk factors for visual loss.
Main Results:
- EMAP was associated with rheumatic fever (86.5%) and heart valve disease (17%).
- Pseudodrusen were detected in over 90% of eyes via CFP and FAF.
- Outer retinal thinning and subfoveal choroidal thickness correlated with visual acuity.
Conclusions:
- Rheumatic fever complications may influence EMAP progression.
- Early diagnosis and treatment of rheumatic fever could improve EMAP outcomes.
- Further longitudinal studies are needed to understand EMAP's natural history.
Keywords:
extensive macular atrophy with pseudodrusenheart valve diseasemultimodal imaging analysisrheumatic feverrisk factorsvisual outcomesMore Related Videos
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