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Updated: May 23, 2025
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Nickel-Catalyzed Adaptive Migration-Enabled Asymmetric Cross-Hydrocarbonylation of Unactivated Alkenes
Yi-Ming Du1, Jia-Ni Lin1, Yu-Long Li2
1Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Shenzhen Grubbs Institute, Guangming Advanced Research Institute, Department of Chemistry, and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P. R. China.
Abstract:
Transition-metal-catalyzed regio- and enantioselective cross-coupling of alkyl metallic species has emerged as a cornerstone in modern organic synthesis, which enables the construction of carbon-carbon and carbon-heteroatom bonds with high precision to facilitate rapid access to important organic targets with molecular complexity. However, the selective formation and utilization of different alkyl metallic intermediates from one precursor under identical conditions remain unknown and challenging. Herein, a Ni-catalyzed adaptive migratory asymmetric cross-hydroacylation of unactivated alkenes for the synthesis of enantioenriched α-arylated ketones has been developed. One alkene serves as a precursor for two different alkyl metallic intermediates by adaptive migration, providing one of the most straightforward pathways to access enantioenriched α-arylated ketones.
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