Targeting STING antagonism in HSV-1: A peptide-based strategy to restore antiviral immunity and suppress viral pathogenesis
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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
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Jiangwei Song1, Mengzhou Xue2, Chunfu Zheng3
1Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
Cell Reports. Medicine
|May 21, 2025
Abstract:
Herpes simplex virus 1 (HSV-1) poses significant threats to human health. Wang et al.1 show that the HSV-1 protein directly antagonizes stimulator of interferon genes (STING). A designed peptide derived from STING can restore virus-subverted immunity and inhibit HSV-1 replication and pathogenesis in mice.

